GC34809
SPP-86
Also known as 3-(2-phenylethynyl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
SPP-86 is a potent and selective cell permeable inhibitor of RET tyrosine kinase, with an IC50 of 8 nM· SPP-86 inhibits RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling, also inhibits RET-induced estrogen receptorα (ERα) phosphorylation in MCF7 cells
ChemicalCAS1357349-91-7MW277.32FormulaC16H15N5
- CAS number
- 1357349-91-7
- Molecular weight
- 277.32
- Formula
- C16H15N5
- Solubility
- Soluble in DMSO
- InChIKey
- JQOIRTDBHMDWMT-UHFFFAOYSA-N
- Catalogue number
- GC34809
- Brand
- GLPBIO
Computed properties PubChem CID 66549796 · XLogP 2.6 · TPSA 69.6 Ų · H-bond donors 1
- XLogP
- 2.6
- TPSA
- 69.6 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Rotatable bonds
- 3
- Heavy atoms
- 21
SMILES CC(C)N1C2=NC=NC(=C2C(=N1)C#CC3=CC=CC=C3)N
Computed descriptors from PubChem (CID 66549796), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il