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Chemical structure of LMP7-IN-1

GC34649

LMP7-IN-1

Also known as [(1R)-2-(1-benzofuran-3-yl)-1-[[(1S,2R,4R)-7-oxabicyclo[2.2.1]heptane-2-carbonyl]amino]ethyl]boronic acid

LMP7-IN-1 is an orally bioavailable, potent, reversible and highly selective immunoproteasome subunit LMP7 (β5i) inhibitor· LMP7-IN-1 exerts high biochemical (IC50=3·6 nM) and cellular (IC50=3·4 nM) potency against the LMP7 subunit· LMP7-IN-1 shows strong antitumor efficacy in multiple myeloma xenograft models· LMP7-IN-1 leads to a significant and prolonged suppression of tumor LMP7 activity and ubiquitinated protein turnover and the induction of apoptosis in multiple myeloma cells

ChemicalCAS2285330-15-4MW329.16FormulaC17H20BNO5
CAS number
2285330-15-4
Molecular weight
329.16
Formula
C17H20BNO5
Solubility
DMSO： 250 mg/mL (759·51 mM)
InChIKey
RFQDLTYXNINJON-OYNZBZHQSA-N
Catalogue number
GC34649
Brand
GLPBIO
Computed properties PubChem CID 138319683 · TPSA 91.9 Ų · H-bond donors 3 · H-bond acceptors 5
TPSA
91.9 Ų
H-bond donors
3
H-bond acceptors
5
Rotatable bonds
5
Heavy atoms
24

SMILES B([C@H](CC1=COC2=CC=CC=C21)NC(=O)[C@@H]3C[C@H]4CC[C@@H]3O4)(O)O

Computed descriptors from PubChem (CID 138319683), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.