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Chemical structure of ALLO-2

GC34463

ALLO-2

Also known as N-[4-[4-(trifluoromethoxy)phenyl]pyrimidin-2-yl]-1H-indazol-5-amine

ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1·5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM

ChemicalCAS1357350-60-7MW371.32FormulaC18H12F3N5O
CAS number
1357350-60-7
Molecular weight
371.32
Formula
C18H12F3N5O
Solubility
DMSO ： 125 mg/mL (336·64 mM)
InChIKey
QTYGEBIJNWMVCW-UHFFFAOYSA-N
Catalogue number
GC34463
Brand
GLPBIO
Computed properties PubChem CID 76848956 · XLogP 4.6 · TPSA 75.7 Ų · H-bond donors 2
XLogP
4.6
TPSA
75.7 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
4
Heavy atoms
27

SMILES C1=CC(=CC=C1C2=NC(=NC=C2)NC3=CC4=C(C=C3)NN=C4)OC(F)(F)F

Computed descriptors from PubChem (CID 76848956), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.