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Chemical structure of PAC

GC34151

PAC

Also known as N-[2-[2-[2-[2-[4-[(Z)-1-[4-[[4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methoxy]phenyl]-2-phenylbut-1-enyl]phenoxy]ethyl-methylamino]-2-oxoethoxy]ethoxy]ethyl]-4-[(3S,4S)-7-cyano-1-[(2-methoxynaphthalen-1-yl)methyl]-4-methyl-3-[[(2S)-2-(methylamino)propanoyl]amino]-2-oxo-3,4-dihydro-1,5-benzodiazepine-5-carbonyl]benzamide

PAC, consists the ADCs linker and PROTACs, conjugated to an antibody· PAC extracts from patent WO2017201449A1, compound LP2· PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab)

ChemicalCAS2158322-33-7MW1674.93FormulaC94H107N13O16
CAS number
2158322-33-7
Molecular weight
1674.93
Formula
C94H107N13O16
Solubility
DMSO： 100 mg/mL (59·70 mM); Water： ＜ 0·1 mg/mL (insoluble)
InChIKey
AAGUYPGVVXJDLD-GGHCKNFKSA-N
Catalogue number
GC34151
Brand
GLPBIO
Computed properties PubChem CID 132144829 · XLogP 10.2 · TPSA 381 Ų · H-bond donors 8
XLogP
10.2
TPSA
381 Ų
H-bond donors
8
H-bond acceptors
18
Rotatable bonds
43
Heavy atoms
123

SMILES CC/C(=C(/C1=CC=C(C=C1)OCCN(C)C(=O)COCCOCCNC(=O)C2=CC=C(C=C2)C(=O)N3[C@H]([C@@H](C(=O)N(C4=C3C=C(C=C4)C#N)CC5=C(C=CC6=CC=CC=C65)OC)NC(=O)[C@H](C)NC)C)\C7=CC=C(C=C7)OCC8=CC=C(C=C8)NC(=O)[C@H](CCCNC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)CCCCCN9C(=O)C=CC9=O)/C1=CC=CC=C1

Computed descriptors from PubChem (CID 132144829), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.