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Chemical structure of M-110

GC34138

M-110

Also known as N-[(E)-1-(4-chloro-2-hydroxyphenyl)propylideneamino]-2-(3-morpholin-4-ylpropylamino)pyridine-4-carboxamide

M-110 is a highly selective, ATP-competitive inhibitor of PIM kinases with a preference for PIM-3 (IC50=47 nM)· M-110 inhibits PIM-1 and PIM-2 with similar IC50s of 2·5 μM· M-110 inhibits the proliferation of prostate cancer cell lines with IC50s of 0·6 to 0·9 μM

ChemicalCAS1395048-49-3MW445.94FormulaC22H28ClN5O3
CAS number
1395048-49-3
Molecular weight
445.94
Formula
C22H28ClN5O3
Solubility
Soluble in DMSO
InChIKey
FXXCNYVQIONABS-LGUFXXKBSA-N
Catalogue number
GC34138
Brand
GLPBIO
Computed properties PubChem CID 136246423 · XLogP 3.1 · TPSA 99.1 Ų · H-bond donors 3
XLogP
3.1
TPSA
99.1 Ų
H-bond donors
3
H-bond acceptors
7
Rotatable bonds
9
Heavy atoms
31

SMILES CC/C(=N\NC(=O)C1=CC(=NC=C1)NCCCN2CCOCC2)/C3=C(C=C(C=C3)Cl)O

Computed descriptors from PubChem (CID 136246423), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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