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Chemical structure of Niraparib R-enantiomer (MK 4827 (R-enantiomer))

GC34120

Niraparib R-enantiomer (MK 4827 (R-enantiomer))

Also known as 2-[4-[(3R)-piperidin-3-yl]phenyl]indazole-7-carboxamide

Niraparib R-enantiomer (MK-4827 R-enantiomer) is an excellent PARP1 inhibitor with IC50 of 2·4 nM

ChemicalCAS1038915-58-0MW320.39FormulaC19H20N4O
CAS number
1038915-58-0
Molecular weight
320.39
Formula
C19H20N4O
Solubility
DMSO : ≥ 32 mg/mL (99·88 mM)
InChIKey
PCHKPVIQAHNQLW-AWEZNQCLSA-N
Catalogue number
GC34120
Brand
GLPBIO
Computed properties PubChem CID 24958199 · XLogP 2.2 · TPSA 72.9 Ų · H-bond donors 2
XLogP
2.2
TPSA
72.9 Ų
H-bond donors
2
H-bond acceptors
3
Rotatable bonds
3
Heavy atoms
24

SMILES C1C[C@@H](CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N

Computed descriptors from PubChem (CID 24958199), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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