Loading...
Chemical structure of Y16

GC34088

Y16

Also known as (4E)-4-[[3-[(3-methylphenyl)methoxy]phenyl]methylidene]-1-phenylpyrazolidine-3,5-dione

Y16 is a specific inhibitor of Leukemia-associated Rho guanine nucleotide exchange factor (LARG) with a Kd value of 76 nM· Y16 is active in blocking the interaction of LARG and related G-protein-coupled Rho GEFs with RhoA· Y16 shows no detectable effect on other diffuse B-cell lymphoma (Dbl) family Rho GEFs, Rho effectors, or a RhoGAP

ChemicalCAS429653-73-6MW384.43FormulaC24H20N2O3
CAS number
429653-73-6
Molecular weight
384.43
Formula
C24H20N2O3
Solubility
DMSO ： 25 mg/mL (65·03 mM);Water ： ＜ 0·1 mg/mL (insoluble)
InChIKey
ITMLWGWTDWJSRZ-PXLXIMEGSA-N
Catalogue number
GC34088
Brand
GLPBIO
Computed properties PubChem CID 989521 · XLogP 4.7 · TPSA 58.6 Ų · H-bond donors 1
XLogP
4.7
TPSA
58.6 Ų
H-bond donors
1
H-bond acceptors
3
Rotatable bonds
5
Heavy atoms
29

SMILES CC1=CC(=CC=C1)COC2=CC=CC(=C2)/C=C/3\C(=O)NN(C3=O)C4=CC=CC=C4

Computed descriptors from PubChem (CID 989521), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.