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Chemical structure of Thalidomide-O-amido-C6-NH2 (TFA)

GC33473

Thalidomide-O-amido-C6-NH2 (TFA)

Also listed as E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate

E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate (Cereblon Ligand-Linker Conjugates 11 TFA), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs

ChemicalCAS1950635-14-9MW544.48FormulaC23H27F3N4O8
CAS number
1950635-14-9
Molecular weight
544.48
Formula
C23H27F3N4O8
Solubility
DMSO: ≥ 105·5 mg/mL (193·76 mM)
InChIKey
KNNGJZWEJKPKSW-UHFFFAOYSA-N
Catalogue number
GC33473
Brand
GLPBIO
Computed properties PubChem CID 121411039 · TPSA 185 Ų · H-bond donors 4 · H-bond acceptors 12
TPSA
185 Ų
H-bond donors
4
H-bond acceptors
12
Rotatable bonds
10
Heavy atoms
38

SMILES C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCC(=O)NCCCCCCN.C(=O)(C(F)(F)F)O

Computed descriptors from PubChem (CID 121411039), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Documents
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