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Chemical structure of MIK665 (S-64315)

GC33295

MIK665 (S-64315)

Also known as (2R)-2-[5-[3-chloro-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-[2-(hydroxymethyl)phenyl]pyrimidin-4-yl]methoxy]phenyl]propanoic acid

MIK665 (S-64315) (S-64315), derived from S63845, is a myeloid cell leukemia sequence 1 (MCL1) inhibitor· MIK665 (S-64315) has an IC50 of 1·81 nM for MCL1

ChemicalCAS1799631-75-6MW875.41FormulaC47H44ClFN6O6S
CAS number
1799631-75-6
Molecular weight
875.41
Formula
C47H44ClFN6O6S
Solubility
DMSO ： ≥ 125 mg/mL (142·79 mM);Water ： ＜ 0·1 mg/mL (insoluble)
InChIKey
NHDQXHYUSYRVEI-LDLOPFEMSA-N
Catalogue number
GC33295
Brand
GLPBIO
Computed properties PubChem CID 118163156 · XLogP 5.9 · TPSA 172 Ų · H-bond donors 2
XLogP
5.9
TPSA
172 Ų
H-bond donors
2
H-bond acceptors
14
Rotatable bonds
16
Heavy atoms
62

SMILES CC1=C(C=CC(=C1Cl)OCCN2CCN(CC2)C)C3=C(SC4=NC=NC(=C34)O[C@H](CC5=CC=CC=C5OCC6=NC(=NC=C6)C7=CC=CC=C7CO)C(=O)O)C8=CC=C(C=C8)F

Computed descriptors from PubChem (CID 118163156), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Documents
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