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Chemical structure of Y06137

GC33264

Y06137

Also known as 5-[1-(cyclohexylmethyl)-6-[(3S)-3-methylmorpholin-4-yl]benzimidazol-2-yl]-3-methyl-1,2-benzoxazole

Y06137 is a potent and selective BET inhibitor for treatment of castration-resistant prostate cancer (CRPC)· Y06137 binds to the BRD4(1) bromodomain with a Kd of 81 nM

ChemicalCAS2226534-49-0MW444.57FormulaC27H32N4O2
CAS number
2226534-49-0
Molecular weight
444.57
Formula
C27H32N4O2
Solubility
DMSO ： 62·5 mg/mL (140·59 mM);Water ： ＜ 0·1 mg/mL (insoluble)
InChIKey
JYCNBHVRGVCHIQ-SFHVURJKSA-N
Catalogue number
GC33264
Brand
GLPBIO
Computed properties PubChem CID 137333445 · XLogP 5.8 · TPSA 56.3 Ų · H-bond donors 0
XLogP
5.8
TPSA
56.3 Ų
H-bond donors
0
H-bond acceptors
5
Rotatable bonds
4
Heavy atoms
33

SMILES C[C@H]1COCCN1C2=CC3=C(C=C2)N=C(N3CC4CCCCC4)C5=CC6=C(C=C5)ON=C6C

Computed descriptors from PubChem (CID 137333445), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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