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Chemical structure of QCA570

GC33217

QCA570

Also known as 3-[7-[5-[4-[2-(5-benzyl-13-methyl-8-oxa-3-thia-1,11,12-triazatricyclo[8.3.0.02,6]trideca-2(6),4,10,12-tetraen-4-yl)ethynyl]pyrazol-1-yl]pent-1-ynyl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione

QCA570 is a PROTAC connected by ligands for Cereblon and BET, with an IC50 of 10 nM for BRD4 BD1 Protein

ChemicalCAS2207569-08-0MW695.79FormulaC39H33N7O4S
CAS number
2207569-08-0
Molecular weight
695.79
Formula
C39H33N7O4S
Solubility
Soluble in DMSO
InChIKey
RTVTYLRQKKDYMQ-UHFFFAOYSA-N
Catalogue number
GC33217
Brand
GLPBIO
Computed properties PubChem CID 134348221 · XLogP 3.9 · TPSA 152 Ų · H-bond donors 1
XLogP
3.9
TPSA
152 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
9
Heavy atoms
51

SMILES CC1=NN=C2N1C3=C(COC2)C(=C(S3)C#CC4=CN(N=C4)CCCC#CC5=C6CN(C(=O)C6=CC=C5)C7CCC(=O)NC7=O)CC8=CC=CC=C8

Computed descriptors from PubChem (CID 134348221), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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