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Chemical structure of Compound E

GC33118

Compound E

Also known as (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]-N-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]propanamide

Compound E is a γ-secretase inhibitor· Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0·24, 0·37, 0·32 nM, respectively

ChemicalCAS209986-17-4MW490.5FormulaC27H24F2N4O3
CAS number
209986-17-4
Molecular weight
490.5
Formula
C27H24F2N4O3
Solubility
DMSO： 100 mg/mL (203·87 mM)
InChIKey
JNGZXGGOCLZBFB-IVCQMTBJSA-N
Catalogue number
GC33118
Brand
GLPBIO
Computed properties PubChem CID 11306390 · XLogP 3.6 · TPSA 90.9 Ų · H-bond donors 2
XLogP
3.6
TPSA
90.9 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
6
Heavy atoms
36

SMILES C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2C(=N1)C3=CC=CC=C3)C)NC(=O)CC4=CC(=CC(=C4)F)F

Computed descriptors from PubChem (CID 11306390), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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