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Chemical structure of RCM-1

GC33117

RCM-1

Also known as 2-(2-oxo-2-thiophen-2-ylethyl)sulfanyl-4,6-dithiophen-2-ylpyridine-3-carbonitrile

RCM-1 is a forkhead box M1 (FOXM1) inhibitor with an EC50 of 0·72 μM in U2OS cells· RCM-1 blocks the nuclear localization and increased the proteasomal degradation of FOXM1· RCM-1 can be used for asthma and other chronic airway diseases research

ChemicalCAS339163-65-4MW424.58FormulaC20H12N2OS4
CAS number
339163-65-4
Molecular weight
424.58
Formula
C20H12N2OS4
Solubility
DMSO : 16·67 mg/mL (39·26 mM)
InChIKey
DCCYTKKDAZEVLY-UHFFFAOYSA-N
Catalogue number
GC33117
Brand
GLPBIO
Computed properties PubChem CID 4273985 · XLogP 5.6 · TPSA 164 Ų · H-bond donors 0
XLogP
5.6
TPSA
164 Ų
H-bond donors
0
H-bond acceptors
7
Rotatable bonds
6
Heavy atoms
27

SMILES C1=CSC(=C1)C2=CC(=NC(=C2C#N)SCC(=O)C3=CC=CS3)C4=CC=CS4

Computed descriptors from PubChem (CID 4273985), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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