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Chemical structure of E3 Ligase Ligand-Linker Conjugates 21

GC33103

E3 Ligase Ligand-Linker Conjugates 21

Also known as N-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide

E3 Ligase Ligand-Linker Conjugates 21 (Cereblon Ligand-Linker Conjugates 3) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology

ChemicalCAS1957236-20-2MW506.51FormulaC23H30N4O9
CAS number
1957236-20-2
Molecular weight
506.51
Formula
C23H30N4O9
Solubility
Soluble in DMSO
InChIKey
QIUJTJGNIBUEJO-UHFFFAOYSA-N
Catalogue number
GC33103
Brand
GLPBIO
Computed properties PubChem CID 121439767 · XLogP -1.9 · TPSA 176 Ų · H-bond donors 3
XLogP
-1.9
TPSA
176 Ų
H-bond donors
3
H-bond acceptors
10
Rotatable bonds
15
Heavy atoms
36

SMILES C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCC(=O)NCCOCCOCCOCCN

Computed descriptors from PubChem (CID 121439767), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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