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Chemical structure of AZ-23 (AZ23)

GC33090

AZ-23 (AZ23)

Also known as 5-chloro-2-N-[(1S)-1-(5-fluoro-2-pyridinyl)ethyl]-4-N-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine

AZ-23 (AZ23) is an ATP-competitive and orally bioavailable Trk kinase A/B/C inhibitor with IC50s of 2 nM (TrkA), 8 nM (TrkB), 24 nM (FGFR1), 52 nM (Flt3), 55 nM (Ret), 84 nM (MuSk), 99 nM (Lck), respectively

ChemicalCAS915720-21-7MW391.83FormulaC17H19ClFN7O
CAS number
915720-21-7
Molecular weight
391.83
Formula
C17H19ClFN7O
Solubility
DMSO ： 125 mg/mL (319·02 mM)
InChIKey
LBVKEEFIPBQIMD-JTQLQIEISA-N
Catalogue number
GC33090
Brand
GLPBIO
Computed properties PubChem CID 16097523 · XLogP 3.7 · TPSA 101 Ų · H-bond donors 3
XLogP
3.7
TPSA
101 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
7
Heavy atoms
27

SMILES C[C@@H](C1=NC=C(C=C1)F)NC2=NC=C(C(=N2)NC3=CC(=NN3)OC(C)C)Cl

Computed descriptors from PubChem (CID 16097523), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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