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Chemical structure of SLV-2436 (SEL201-88)

GC32937

SLV-2436 (SEL201-88)

Also known as 5-(3-amino-1H-indazol-6-yl)-1-[(3-chlorophenyl)methyl]pyridin-2-one

SLV-2436 (SEL201-88) is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC50s of 10·8 nM and 5·4 nM, respectively

ChemicalCAS2095704-43-9MW350.8FormulaC19H15ClN4O
CAS number
2095704-43-9
Molecular weight
350.8
Formula
C19H15ClN4O
Solubility
DMSO : ≥ 100 mg/mL (285·06 mM)
InChIKey
YQVUADHJKWJHAF-UHFFFAOYSA-N
Catalogue number
GC32937
Brand
GLPBIO
Computed properties PubChem CID 129052025 · XLogP 3 · TPSA 75 Ų · H-bond donors 2
XLogP
3
TPSA
75 Ų
H-bond donors
2
H-bond acceptors
3
Rotatable bonds
3
Heavy atoms
25

SMILES C1=CC(=CC(=C1)Cl)CN2C=C(C=CC2=O)C3=CC4=C(C=C3)C(=NN4)N

Computed descriptors from PubChem (CID 129052025), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Documents
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