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Chemical structure of E3 ligase Ligand-Linker Conjugates 10

GC32902

E3 ligase Ligand-Linker Conjugates 10

Also known as (2S,4R)-1-[(2S)-2-[[2-[2-(6-chlorohexoxy)ethoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

E3 ligase Ligand-Linker Conjugates 10 (VH032-PEG2-C4-Cl) is a conjugate of ligands for E3 and 13-atom-length linker· The connector of linker is Halogen group· E3 ligase Ligand-Linker Conjugates 10 incorporates the (S,R,S)-AHPC based VHL ligand and an alkyl/ether-based linker· E3 ligase Ligand-Linker Conjugates 10 is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays

ChemicalCAS1835705-57-1MW651.26FormulaC32H47ClN4O6S
CAS number
1835705-57-1
Molecular weight
651.26
Formula
C32H47ClN4O6S
Solubility
DMSO ： ≥ 50 mg/mL (76·77 mM)
InChIKey
VVGFRQKHZOZAAG-UWPQIUOOSA-N
Catalogue number
GC32902
Brand
GLPBIO
Computed properties PubChem CID 129072774 · XLogP 4.1 · TPSA 158 Ų · H-bond donors 3
XLogP
4.1
TPSA
158 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
18
Heavy atoms
44

SMILES CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)COCCOCCCCCCCl)O

Computed descriptors from PubChem (CID 129072774), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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