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Chemical structure of PD0166285

GC32853

PD0166285

Also known as 6-(2,6-dichlorophenyl)-2-[4-[2-(diethylamino)ethoxy]anilino]-8-methylpyrido[2,3-d]pyrimidin-7-one

PD0166285, a substrate of P-gp, is a WEE1 inhibitor and a weak Myt1 inhibitor with IC50 values of 24 and 72 nM, respectively· PD0166285 exhibits an IC50 of 3·433 μM for Chk1

ChemicalCAS185039-89-8MW512.43FormulaC26H27Cl2N5O2
CAS number
185039-89-8
Molecular weight
512.43
Formula
C26H27Cl2N5O2
Solubility
DMSO ： 65 mg/mL (126·85 mM);Water ： ＜ 0·1 mg/mL (insoluble)
InChIKey
IFPPYSWJNWHOLQ-UHFFFAOYSA-N
Catalogue number
GC32853
Brand
GLPBIO
Computed properties PubChem CID 5311382 · XLogP 5.6 · TPSA 70.6 Ų · H-bond donors 1
XLogP
5.6
TPSA
70.6 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
9
Heavy atoms
35

SMILES CCN(CC)CCOC1=CC=C(C=C1)NC2=NC=C3C=C(C(=O)N(C3=N2)C)C4=C(C=CC=C4Cl)Cl

Computed descriptors from PubChem (CID 5311382), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
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