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Chemical structure of Pico145 (HC-608)

GC32849

Pico145 (HC-608)

Also known as 7-[(4-chlorophenyl)methyl]-1-(3-hydroxypropyl)-3-methyl-8-[3-(trifluoromethoxy)phenoxy]purine-2,6-dione

Pico145 (HC-608) (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels, inhibits (-)-englerin A-activated TRPC4/TRPC5 channels, with IC50s of 0·349 and 1·3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8

ChemicalCAS1628287-16-0MW524.88FormulaC23H20ClF3N4O5
CAS number
1628287-16-0
Molecular weight
524.88
Formula
C23H20ClF3N4O5
Solubility
DMSO ： ≥ 125 mg/mL (238·15 mM)
InChIKey
PRJHEJGMSOBHTO-UHFFFAOYSA-N
Catalogue number
GC32849
Brand
GLPBIO
Computed properties PubChem CID 85473438 · XLogP 4.5 · TPSA 97.1 Ų · H-bond donors 1
XLogP
4.5
TPSA
97.1 Ų
H-bond donors
1
H-bond acceptors
9
Rotatable bonds
8
Heavy atoms
36

SMILES CN1C2=C(C(=O)N(C1=O)CCCO)N(C(=N2)OC3=CC(=CC=C3)OC(F)(F)F)CC4=CC=C(C=C4)Cl

Computed descriptors from PubChem (CID 85473438), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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