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Chemical structure of PP58

GC32835

PP58

Also known as 2-[4-(2-aminoethoxy)anilino]-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidin-7-one

PP58 is a pyrido[2,3-d]pyrimidine-based compound that inhibits PDGFR, FGFR and Src family activities with nanomolar IC50 values

ChemicalCAS212391-58-7MW456.32FormulaC22H19Cl2N5O2
CAS number
212391-58-7
Molecular weight
456.32
Formula
C22H19Cl2N5O2
Solubility
Soluble in DMSO
InChIKey
MAXZESONWXTISA-UHFFFAOYSA-N
Catalogue number
GC32835
Brand
GLPBIO
Computed properties PubChem CID 5327904 · XLogP 3.9 · TPSA 93.4 Ų · H-bond donors 2
XLogP
3.9
TPSA
93.4 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
6
Heavy atoms
31

SMILES CN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=CC=C3Cl)Cl)NC4=CC=C(C=C4)OCCN

Computed descriptors from PubChem (CID 5327904), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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