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Chemical structure of CUDC-427 (GDC-0917)

GC32781

CUDC-427 (GDC-0917)

Also known as (2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)propanoyl]amino]acetyl]-N-[2-(1,3-oxazol-2-yl)-4-phenyl-1,3-thiazol-5-yl]pyrrolidine-2-carboxamide

CUDC-427 (GDC-0917) is a potent second-generation pan-selective IAP antagonist, used for treatment of various cancers

ChemicalCAS1446182-94-0MW564.7FormulaC29H36N6O4S
CAS number
1446182-94-0
Molecular weight
564.7
Formula
C29H36N6O4S
Solubility
DMSO ： ≥ 61 mg/mL (108·02 mM)
InChIKey
HSHPBORBOJIXSQ-HARLFGEKSA-N
Catalogue number
GC32781
Brand
GLPBIO
Computed properties PubChem CID 71600094 · XLogP 4 · TPSA 158 Ų · H-bond donors 3
XLogP
4
TPSA
158 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
9
Heavy atoms
40

SMILES C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C(=O)NC3=C(N=C(S3)C4=NC=CO4)C5=CC=CC=C5)NC

Computed descriptors from PubChem (CID 71600094), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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