Loading...
Chemical structure of TAS6417

GC32752

TAS6417

Also known as N-[(8S)-4-amino-6-methyl-5-quinolin-3-yl-8,9-dihydropyrimido[5,4-b]indolizin-8-yl]prop-2-enamide

TAS6417 (CLN-081) is a highly effective, orally active and pan-mutation-selective EGFR tyrosine kinase inhibitor with a unique scaffold fitting into the ATP-binding site of the EGFR hinge region, with IC50 values ranging from 1·1-8·0 nM

ChemicalCAS1661854-97-2MW396.44FormulaC23H20N6O
CAS number
1661854-97-2
Molecular weight
396.44
Formula
C23H20N6O
Solubility
DMSO ： ≥ 125 mg/mL (315·31 mM)
InChIKey
MKCYPWYURWOKST-INIZCTEOSA-N
Catalogue number
GC32752
Brand
GLPBIO
Computed properties PubChem CID 117918742 · XLogP 2.3 · TPSA 98.7 Ų · H-bond donors 2
XLogP
2.3
TPSA
98.7 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
3
Heavy atoms
30

SMILES CC1=C[C@@H](CN2C1=C(C3=C(N=CN=C32)N)C4=CC5=CC=CC=C5N=C4)NC(=O)C=C

Computed descriptors from PubChem (CID 117918742), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.