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Chemical structure of CCT-251921

GC32741

CCT-251921

Also known as 8-[2-amino-3-chloro-5-(1-methylindazol-5-yl)-4-pyridinyl]-2,8-diazaspiro[4.5]decan-1-one

CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor with an IC50 of 2·3 nM

ChemicalCAS1607837-31-9MW410.9FormulaC21H23ClN6O
CAS number
1607837-31-9
Molecular weight
410.9
Formula
C21H23ClN6O
Solubility
DMSO ： ≥ 28 mg/mL (68·14 mM)
InChIKey
VPJXPDLMACOGIZ-UHFFFAOYSA-N
Catalogue number
GC32741
Brand
GLPBIO
Computed properties PubChem CID 74222277 · XLogP 2.3 · TPSA 89.1 Ų · H-bond donors 2
XLogP
2.3
TPSA
89.1 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
2
Heavy atoms
29

SMILES CN1C2=C(C=C(C=C2)C3=CN=C(C(=C3N4CCC5(CCNC5=O)CC4)Cl)N)C=N1

Computed descriptors from PubChem (CID 74222277), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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