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Chemical structure of ND-646

GC32706

ND-646

Also known as 2-[1-[(2R)-2-(2-methoxyphenyl)-2-(oxan-4-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxothieno[2,3-d]pyrimidin-3-yl]-2-methylpropanamide

ND-646 is an orally bioavailable and steric inhibitor of acetyl-CoA carboxylase (ACC) with IC50s of 3·5 nM and 4·1 nM for recombinant hACC1 and hACC2, respectively

ChemicalCAS1434639-57-2MW568.64FormulaC28H32N4O7S
CAS number
1434639-57-2
Molecular weight
568.64
Formula
C28H32N4O7S
Solubility
DMSO ： ≥ 100 mg/mL (175·86 mM)
InChIKey
HSRWXLIYNCKHRZ-FQEVSTJZSA-N
Catalogue number
GC32706
Brand
GLPBIO
Computed properties PubChem CID 71570560 · XLogP 2.6 · TPSA 166 Ų · H-bond donors 1
XLogP
2.6
TPSA
166 Ų
H-bond donors
1
H-bond acceptors
9
Rotatable bonds
9
Heavy atoms
40

SMILES CC1=C(SC2=C1C(=O)N(C(=O)N2C[C@@H](C3=CC=CC=C3OC)OC4CCOCC4)C(C)(C)C(=O)N)C5=NC=CO5

Computed descriptors from PubChem (CID 71570560), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.