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Chemical structure of Branaplam

GC32702

Branaplam

Also listed as Branaplam (LMI070)

Branaplam (LMI070) (LMI070; NVS-SM1) is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN· Branaplam (LMI070) inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6·3 μM· Branaplam (LMI070) elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model

ChemicalCAS1562338-42-4MW393.48FormulaC22H27N5O2
CAS number
1562338-42-4
Molecular weight
393.48
Formula
C22H27N5O2
Solubility
DMSO ： 6·12 mg/mL (15·55 mM)
InChIKey
STWTUEAWRAIWJG-UHFFFAOYSA-N
Catalogue number
GC32702
Brand
GLPBIO
Computed properties PubChem CID 135565042 · XLogP 2.7 · TPSA 96 Ų · H-bond donors 3
XLogP
2.7
TPSA
96 Ų
H-bond donors
3
H-bond acceptors
6
Rotatable bonds
4
Heavy atoms
29

SMILES CC1(CC(CC(N1)(C)C)OC2=NN=C(C=C2)C3=C(C=C(C=C3)C4=CNN=C4)O)C

Computed descriptors from PubChem (CID 135565042), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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