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Chemical structure of JPH203 (KYT-0353)

GC32690

JPH203 (KYT-0353)

Also known as (2S)-2-amino-3-[4-[(5-amino-2-phenyl-1,3-benzoxazol-7-yl)methoxy]-3,5-dichlorophenyl]propanoic acid

JPH203 (KYT-0353), a selective L-type amino acid transporter 1 inhibitor, significantly inhibited leucine uptake and cell growth in HT-29 YD-38 and leukemia cells, with IC50 values of 0·06 μM and 4·1 μM, respectively

ChemicalCAS1037592-40-7MW472.32FormulaC23H19Cl2N3O4
CAS number
1037592-40-7
Molecular weight
472.32
Formula
C23H19Cl2N3O4
Solubility
0·1N hydrochloric acid ： 7·3 mg/mL (15·46 mM);Methanol ： 6·4 mg/mL (13·55 mM);DMSO ： ＞100mg/ml (insoluble or slightly soluble)
InChIKey
XNRZJPQTMQZBCE-SFHVURJKSA-N
Catalogue number
GC32690
Brand
GLPBIO
Computed properties PubChem CID 24853505 · XLogP 2.1 · TPSA 125 Ų · H-bond donors 3
XLogP
2.1
TPSA
125 Ų
H-bond donors
3
H-bond acceptors
7
Rotatable bonds
7
Heavy atoms
32

SMILES C1=CC=C(C=C1)C2=NC3=CC(=CC(=C3O2)COC4=C(C=C(C=C4Cl)C[C@@H](C(=O)O)N)Cl)N

Computed descriptors from PubChem (CID 24853505), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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