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Chemical structure of Islatravir (MK-8591)

GC32306

Islatravir (MK-8591)

Also known as (2R,3S,5R)-5-(6-amino-2-fluoropurin-9-yl)-2-ethynyl-2-(hydroxymethyl)oxolan-3-ol

Islatravir (MK-8591) (MK-8591) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0·068 nM, 3·1 nM and 0·15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively

ChemicalCAS865363-93-5MW293.25FormulaC12H12FN5O3
CAS number
865363-93-5
Molecular weight
293.25
Formula
C12H12FN5O3
Solubility
DMSO： 20·83 mg/mL (71·03 mM; ultrasonic and adjust pH to 3 with HCl); Water： 3·57 mg/mL (12·17 mM; ultrasonic and warming and heat to 60°C)
InChIKey
IKKXOSBHLYMWAE-QRPMWFLTSA-N
Catalogue number
GC32306
Brand
GLPBIO
Computed properties PubChem CID 6483431 · XLogP -0.6 · TPSA 119 Ų · H-bond donors 3
XLogP
-0.6
TPSA
119 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
3
Heavy atoms
21

SMILES C#C[C@]1([C@H](C[C@@H](O1)N2C=NC3=C(N=C(N=C32)F)N)O)CO

Computed descriptors from PubChem (CID 6483431), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.