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Chemical structure of Leu-AMS

GC32121

Leu-AMS

Also known as [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl N-[(2S)-2-amino-4-methylpentanoyl]sulfamate

Leu-AMS (compound 6), a leucine analogue, is a potent inhibitor of leucyl-tRNA synthetase (LRS) with an IC50 of 22·34 nM, which inhibits the catalytic activity of LRS but did not affect the leucine-induced mTORC1 activation

ChemicalCAS288591-93-5MW459.48FormulaC16H25N7O7S
CAS number
288591-93-5
Molecular weight
459.48
Formula
C16H25N7O7S
Solubility
DMSO ： ≥ 49·17 mg/mL (107·01 mM)
InChIKey
XFEDFDTWJLGMBO-LEJQEAHTSA-N
Catalogue number
GC32121
Brand
GLPBIO
Computed properties PubChem CID 5288690 · XLogP -2 · TPSA 226 Ų · H-bond donors 5
XLogP
-2
TPSA
226 Ų
H-bond donors
5
H-bond acceptors
12
Rotatable bonds
8
Heavy atoms
31

SMILES CC(C)C[C@@H](C(=O)NS(=O)(=O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)O)N

Computed descriptors from PubChem (CID 5288690), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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