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Chemical structure of Kira8

GC31879

Kira8

Also known as 2-chloro-N-[6-methyl-5-[[3-[2-[[(3S)-piperidin-3-yl]amino]pyrimidin-4-yl]-2-pyridinyl]oxy]naphthalen-1-yl]benzenesulfonamide

Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5·9 nM

ChemicalCAS1630086-20-2MW601.12FormulaC31H29ClN6O3S
CAS number
1630086-20-2
Molecular weight
601.12
Formula
C31H29ClN6O3S
Solubility
DMSO ： 65 mg/mL (108·13 mM);Water ： ＜ 0·1 mg/mL (insoluble)
InChIKey
XMWUCMFVDXDRDE-NRFANRHFSA-N
Catalogue number
GC31879
Brand
GLPBIO
Computed properties PubChem CID 118721244 · XLogP 5.9 · TPSA 127 Ų · H-bond donors 3
XLogP
5.9
TPSA
127 Ų
H-bond donors
3
H-bond acceptors
9
Rotatable bonds
8
Heavy atoms
42

SMILES CC1=C(C2=C(C=C1)C(=CC=C2)NS(=O)(=O)C3=CC=CC=C3Cl)OC4=C(C=CC=N4)C5=NC(=NC=C5)N[C@H]6CCCNC6

Computed descriptors from PubChem (CID 118721244), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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