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Chemical structure of PKC-IN-1

GC31711

PKC-IN-1

Also known as [(2S,5R)-2,5-dimethyl-4-(oxan-4-ylmethyl)piperazin-1-yl]-[3-[(5-fluoro-2-methylpyrimidin-4-yl)amino]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-d]pyrazol-5-yl]methanone

PKC-IN-1 is a potent, ATP-competitive and reversible inhibitor of conventional PKC enzymes with Kis of 5·3 and 10·4 nM for human PKCβ and PKCα, and IC50s of 2·3, 8·1, 7·6, 25·6, 57·5, 314, 808 nM for PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε, respectively

ChemicalCAS1046787-18-1MW500.61FormulaC25H37FN8O2
CAS number
1046787-18-1
Molecular weight
500.61
Formula
C25H37FN8O2
Solubility
DMSO ： ≥ 25 mg/mL (49·94 mM)
InChIKey
DKXZBPBWIGORKP-CVEARBPZSA-N
Catalogue number
GC31711
Brand
GLPBIO
Computed properties PubChem CID 25155745 · XLogP 2 · TPSA 103 Ų · H-bond donors 2
XLogP
2
TPSA
103 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
4
Heavy atoms
36

SMILES C[C@H]1CN([C@@H](CN1C(=O)N2CC3=C(C2(C)C)NN=C3NC4=NC(=NC=C4F)C)C)CC5CCOCC5

Computed descriptors from PubChem (CID 25155745), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.