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Chemical structure of L-873724

GC31465

L-873724

Also known as (2S)-N-(cyanomethyl)-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]pentanamide

L-873724 is a potent, orally bioavailable, selective and reversible non-basic cathepsin K inhibitor, with IC50s of 0·2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively

ChemicalCAS603139-12-4MW481.53FormulaC23H26F3N3O3S
CAS number
603139-12-4
Molecular weight
481.53
Formula
C23H26F3N3O3S
Solubility
Soluble in DMSO
InChIKey
VYFDSJLOCIGIKP-SFTDATJTSA-N
Catalogue number
GC31465
Brand
GLPBIO
Computed properties PubChem CID 9913088 · XLogP 4.2 · TPSA 107 Ų · H-bond donors 2
XLogP
4.2
TPSA
107 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
9
Heavy atoms
33

SMILES CC(C)C[C@@H](C(=O)NCC#N)N[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)S(=O)(=O)C)C(F)(F)F

Computed descriptors from PubChem (CID 9913088), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.