GC31357
LY 345899
Also known as (2S)-2-[[4-(3-amino-1,9-dioxo-5,6,6a,7-tetrahydro-2H-imidazo[1,5-f]pteridin-8-yl)benzoyl]amino]pentanedioic acid
LY 345899 is a Folate analog and is a methylene tetrahydrofolate dehydrogenase (MTHFD1; DC301) and MTHFD2 inbhibitor with IC50 values of 96 nM and 663 nM, respectively and a Ki of 18 nM for MTHFD1
ChemicalCAS10538-99-5MW471.42FormulaC20H21N7O7
- CAS number
- 10538-99-5
- Molecular weight
- 471.42
- Formula
- C20H21N7O7
- Solubility
- DMSO ： 125 mg/mL (265·16 mM)
- InChIKey
- JSNFRYBHBVDHSG-KIYNQFGBSA-N
- Catalogue number
- GC31357
- Brand
- GLPBIO
Computed properties PubChem CID 135484014 · XLogP -1.6 · TPSA 207 Ų · H-bond donors 6
- XLogP
- -1.6
- TPSA
- 207 Ų
- H-bond donors
- 6
- H-bond acceptors
- 9
- Rotatable bonds
- 7
- Heavy atoms
- 34
SMILES C1C2CN(C(=O)N2C3=C(N1)N=C(NC3=O)N)C4=CC=C(C=C4)C(=O)N[C@@H](CCC(=O)O)C(=O)O
Computed descriptors from PubChem (CID 135484014), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il