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Chemical structure of A-437203 (Lu201640)

GC31214

A-437203 (Lu201640)

Also known as 2-[3-[4-[2-tert-butyl-6-(trifluoromethyl)pyrimidin-4-yl]piperazin-1-yl]propylsulfanyl]-1H-pyrimidin-6-one

A-437203 (Lu201640) is a selective D3 receptor antagonist with Ki of 71, 1·6, and 6220 nM for D2, D3, and D4 receptors, respectively

ChemicalCAS220519-06-2MW456.53FormulaC20H27F3N6OS
CAS number
220519-06-2
Molecular weight
456.53
Formula
C20H27F3N6OS
Solubility
DMSO : ≥ 125 mg/mL (273·80 mM)
InChIKey
KXVAICSRMHXLJN-UHFFFAOYSA-N
Catalogue number
GC31214
Brand
GLPBIO
Computed properties PubChem CID 9916104 · XLogP 3.4 · TPSA 99 Ų · H-bond donors 1
XLogP
3.4
TPSA
99 Ų
H-bond donors
1
H-bond acceptors
10
Rotatable bonds
7
Heavy atoms
31

SMILES CC(C)(C)C1=NC(=CC(=N1)N2CCN(CC2)CCCSC3=NC=CC(=O)N3)C(F)(F)F

Computed descriptors from PubChem (CID 9916104), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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