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Chemical structure of PE859

GC30801

PE859

Also known as 6-[(E)-2-[5-[(E)-2-[2-methoxy-4-(pyridin-2-ylmethoxy)phenyl]ethenyl]-1H-pyrazol-3-yl]ethenyl]-1H-indole

PE859 is a potent inhibitor of both tau and Aβ aggregation with IC50 values of 0·66 and 1·2 μM, respectively

ChemicalCAS1402727-29-0MW448.52FormulaC28H24N4O2
CAS number
1402727-29-0
Molecular weight
448.52
Formula
C28H24N4O2
Solubility
DMSO ： 50 mg/mL (111·48 mM);Water ： ＜ 0·1 mg/mL (insoluble)
InChIKey
AMBZHNVCLPHAKA-NSJFVGFPSA-N
Catalogue number
GC30801
Brand
GLPBIO
Computed properties PubChem CID 66571561 · XLogP 5.4 · TPSA 75.8 Ų · H-bond donors 2
XLogP
5.4
TPSA
75.8 Ų
H-bond donors
2
H-bond acceptors
4
Rotatable bonds
8
Heavy atoms
34

SMILES COC1=C(C=CC(=C1)OCC2=CC=CC=N2)/C=C/C3=CC(=NN3)/C=C/C4=CC5=C(C=C4)C=CN5

Computed descriptors from PubChem (CID 66571561), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.