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Chemical structure of Rubone

GC26832

Rubone

Also known as (E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(2,4,5-trimethoxyphenyl)prop-2-en-1-one

Rubone (2'-Hydroxy-2,4,4',5,6'-pentamethoxychalcone), a natural product and a modulator of miR-34a (microRNA-34), upregulates miR-34a expression in a p53-dependent manner, which in turn downregulates the expression of downstream targets Bcl-2, cyclin-D1, CDK6, SIRT1, and FOXP1, thereby inhibiting tumor growth and reversal of hepatocellular carcinoma (HCC) and chemoresistance in prostate cancer

ChemicalCAS73694-15-2MW374.38FormulaC20H22O7
CAS number
73694-15-2
Molecular weight
374.38
Formula
C20H22O7
Solubility
DMSO： 1 mg/mL (2·67 mM), Sonication is recommended·
InChIKey
VHCQVGQULWFQTM-VOTSOKGWSA-N
Catalogue number
GC26832
Brand
GLPBIO
Computed properties PubChem CID 5951499 · XLogP 3.7 · TPSA 83.5 Ų · H-bond donors 1
XLogP
3.7
TPSA
83.5 Ų
H-bond donors
1
H-bond acceptors
7
Rotatable bonds
8
Heavy atoms
27

SMILES COC1=CC(=C(C(=C1)OC)C(=O)/C=C/C2=CC(=C(C=C2OC)OC)OC)O

Computed descriptors from PubChem (CID 5951499), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.