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Chemical structure of Harringtonolide

GC26727

Harringtonolide

Also known as (11S,12R,13S,19R)-8,19-dimethyl-14,17-dioxahexacyclo[13.3.1.01,11.04,10.09,13.012,16]nonadeca-4,7,9-triene-6,18-dione

Harringtonolide is a potent RACK1 inhibitor (IC50=39·66 μM in A375 cells)· Harringtonolide inhibits the epithelial-mesenchymal transition (EMT) process and cell proliferation by affecting the interaction between FAK and RACK1· Harringtonolide has plant growth inhibitory, antiviral, anti-inflammatory, and antiproliferation activities

ChemicalCAS64761-48-4MW310.34FormulaC19H18O4
CAS number
64761-48-4
Molecular weight
310.34
Formula
C19H18O4
Solubility
DMSO ： 5 mg/mL
InChIKey
QNJIIOHVULPMRL-OFSDVKARSA-N
Catalogue number
GC26727
Brand
GLPBIO
Computed properties PubChem CID 188356 · XLogP 0.3 · TPSA 52.6 Ų · H-bond donors 0
XLogP
0.3
TPSA
52.6 Ų
H-bond donors
0
H-bond acceptors
4
Rotatable bonds
0
Heavy atoms
23

SMILES C[C@H]1C2C3[C@@H]4[C@@H]5C1(CCC6=CC(=O)C=C(C(=C56)[C@H]4O2)C)C(=O)O3

Computed descriptors from PubChem (CID 188356), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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