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Chemical structure of BMS-986365

GC26491

BMS-986365

Also known as 2-[(2R)-4-[2-[4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl]-2-ethylphenoxy]ethyl]-2-methylpiperazin-1-yl]-N-[3-[(2,6-dioxopiperidin-3-yl)amino]phenyl]acetamide

BMS-986365 (CC-94676) is an orally available, selective and highly potent AR degrader with potential anticancer activity that inhibits AR signaling and suppresses tumor growth for the study of prostate cancer

ChemicalCAS2446928-30-7MW818.91FormulaC41H45F3N8O5S
CAS number
2446928-30-7
Molecular weight
818.91
Formula
C41H45F3N8O5S
Solubility
DMSO： 80 mg/mL (97·69 mM), Sonication is recommended·
InChIKey
YUVGVJYLOFTILT-NHYGQJMQSA-N
Catalogue number
GC26491
Brand
GLPBIO
Computed properties PubChem CID 149429863 · XLogP 5.4 · TPSA 182 Ų · H-bond donors 3
XLogP
5.4
TPSA
182 Ų
H-bond donors
3
H-bond acceptors
13
Rotatable bonds
12
Heavy atoms
58

SMILES CCC1=C(C=CC(=C1)N2C(=S)N(C(=O)C2(C)C)C3=CC(=C(C=C3)C#N)C(F)(F)F)OCCN4CCN([C@@H](C4)C)CC(=O)NC5=CC=CC(=C5)NC6CCC(=O)NC6=O

Computed descriptors from PubChem (CID 149429863), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Documents
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