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Chemical structure of SNS-314

GC25940

SNS-314

Also known as 1-(3-chlorophenyl)-3-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl]urea

SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively· It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2· Phase 1

ChemicalCAS1057249-41-8MW430.93FormulaC18H15ClN6OS2
CAS number
1057249-41-8
Molecular weight
430.93
Formula
C18H15ClN6OS2
Solubility
DMSO： 100 mg/mL (232·06 mM);Water： Insoluble;Ethanol： Insoluble
InChIKey
FAYAUAZLLLJJGH-UHFFFAOYSA-N
Catalogue number
GC25940
Brand
GLPBIO
Computed properties PubChem CID 24995524 · XLogP 4.2 · TPSA 148 Ų · H-bond donors 3
XLogP
4.2
TPSA
148 Ų
H-bond donors
3
H-bond acceptors
7
Rotatable bonds
6
Heavy atoms
28

SMILES C1=CC(=CC(=C1)Cl)NC(=O)NC2=NC=C(S2)CCNC3=NC=NC4=C3SC=C4

Computed descriptors from PubChem (CID 24995524), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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