GC25743
PIM447 (LGH447)
PIM447 (LGH447) is a novel pan-PIM kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively· It also inhibits GSK3β, PKN1, and PKCτ, but at a significantly lower potency with IC50 between 1 and 5 μM (>105-fold differential relative to the Ki on PIMs)· PIM447 induces apoptosis
ChemicalMW476.92FormulaC24H23F3N4O·HCl
- CAS number
- —
- Molecular weight
- 476.92
- Formula
- C24H23F3N4O·HCl
- Solubility
- DMSO： 88 mg/mL (184·52 mM);Water： Insoluble;Ethanol： 88 mg/mL (184·52 mM)
- Catalogue number
- GC25743
- Brand
- GLPBIO
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il