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Chemical structure of M2912

GC25603

M2912

Also known as 3-[4-(2-hydroxypropan-2-yl)phenyl]-6-methyl-2H-pyrrolo[1,2-a]pyrazin-1-one

M2912 (MSC2504877) is a very potent TNKS1/TNKS2 inhibitor (IC50=0·6 nM for TNKS1) with exquisite selectivity over other PARP family enzymes and favorable compound properties· This inhibitor potently modulates the Wnt/β-catenin pathway by elevating the levels of axin2 (EC50=17 nM) and tankyrase in DLD1 cells in a dose-dependent manner resulting in reduced cellular Wnt reporter activity

ChemicalCAS1460286-21-8MW282.34FormulaC17H18N2O2
CAS number
1460286-21-8
Molecular weight
282.34
Formula
C17H18N2O2
Solubility
DMSO： 56 mg/mL (198·34 mM);Water： Insoluble;Ethanol： 6 mg/mL (21·25 mM)
InChIKey
MPXAEYSGFKRDQM-UHFFFAOYSA-N
Catalogue number
GC25603
Brand
GLPBIO
Computed properties PubChem CID 71765184 · XLogP 1.9 · TPSA 54.3 Ų · H-bond donors 2
XLogP
1.9
TPSA
54.3 Ų
H-bond donors
2
H-bond acceptors
2
Rotatable bonds
2
Heavy atoms
21

SMILES CC1=CC=C2N1C=C(NC2=O)C3=CC=C(C=C3)C(C)(C)O

Computed descriptors from PubChem (CID 71765184), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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