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Chemical structure of Brepocitinib

GC25168

Brepocitinib

Also listed as Brepocitinib (PF-06700841)

Brepocitinib (PF-06700841, PF-841) is a potent inhibitor of Tyk2 and Jak1 with IC50s of 23 nM, 17 nM, 77 nM for Tyk2, Jak1 and Jak2 respectively· It has appropriate in-family selectivity against JAK2 and JAK3

ChemicalCAS1883299-62-4MW389.4FormulaC18H21F2N7O
CAS number
1883299-62-4
Molecular weight
389.4
Formula
C18H21F2N7O
Solubility
DMSO： 78 mg/mL (200·31 mM);Water： Insoluble;Ethanol： 78 mg/mL (200·31 mM)
InChIKey
BUWBRTXGQRBBHG-MJBXVCDLSA-N
Catalogue number
GC25168
Brand
GLPBIO
Computed properties PubChem CID 118878093 · XLogP 1.5 · TPSA 79.2 Ų · H-bond donors 1
XLogP
1.5
TPSA
79.2 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
4
Heavy atoms
28

SMILES CN1C=C(C=N1)NC2=NC=CC(=N2)N3C[C@H]4CC[C@@H](C3)N4C(=O)[C@@H]5CC5(F)F

Computed descriptors from PubChem (CID 118878093), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.