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Chemical structure of (E/Z)-BCI

GC25000

(E/Z)-BCI

Also known as (2Z)-2-benzylidene-3-(cyclohexylamino)-3H-inden-1-one

(E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13·3 μM and 8·0 μM for DUSP6 and DUSP1 in cells, respectively· (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells

ChemicalCAS15982-84-0MW317.42FormulaC22H23NO
CAS number
15982-84-0
Molecular weight
317.42
Formula
C22H23NO
Solubility
DMSO： 63 mg/mL (198·48 mM);Water： Insoluble;Ethanol： 20 mg/mL (63·01 mM)
InChIKey
XJDKPLZUXCIMIS-HKWRFOASSA-N
Catalogue number
GC25000
Brand
GLPBIO
Computed properties PubChem CID 5475586 · XLogP 4.7 · TPSA 29.1 Ų · H-bond donors 1
XLogP
4.7
TPSA
29.1 Ų
H-bond donors
1
H-bond acceptors
2
Rotatable bonds
3
Heavy atoms
24

SMILES C1CCC(CC1)NC\2C3=CC=CC=C3C(=O)/C2=C\C4=CC=CC=C4

Computed descriptors from PubChem (CID 5475586), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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