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Chemical structure of Notch inhibitor 1

GC19995

Notch inhibitor 1

Also known as (2S,3R)-N'-[(3S)-5-(3-fluorophenyl)-9-methyl-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide

Notch inhibitor 1 is a potent Notch inhibitor, with IC50s of 7·8 and 8·5 nM for Notch 1 and Notch 3, respectively· Used in the research of cancer

ChemicalCAS1584647-27-7MW574.49FormulaC26H25F7N4O3
CAS number
1584647-27-7
Molecular weight
574.49
Formula
C26H25F7N4O3
Solubility
DMSO ： 13·12 mg/mL (22·84 mM; ultrasonic and warming and heat to 70°C)
InChIKey
SRJNRAQUSAVENA-GSHUGGBRSA-N
Catalogue number
GC19995
Brand
GLPBIO
Computed properties PubChem CID 73388393 · XLogP 4.8 · TPSA 114 Ų · H-bond donors 3
XLogP
4.8
TPSA
114 Ų
H-bond donors
3
H-bond acceptors
11
Rotatable bonds
9
Heavy atoms
40

SMILES CC1=C2C(=CC=C1)C(=N[C@@H](C(=O)N2)NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(=O)N)C3=CC(=CC=C3)F

Computed descriptors from PubChem (CID 73388393), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.