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Chemical structure of Z433927330

GC19902

Z433927330

Also known as ethyl 4-[(4-pyrazol-1-ylphenyl)methylcarbamoylamino]benzoate

Z433927330 is a potent and selective inhibitor of Aquaporin-7 (AQP7), less potently inhibits AQP3 and AQPs9, with IC50s of ~0·2 ?M, ~0·7 ?M and ~1·1 ?M for mAQP7, mAQP3 and mAQP9, respectively

ChemicalCAS1005883-72-6MW364.4FormulaC₂₀H₂₀N₄O₃
CAS number
1005883-72-6
Molecular weight
364.4
Formula
C₂₀H₂₀N₄O₃
Solubility
DMSO : ≥ 280 mg/mL (768·39 mM)
InChIKey
KQUKHINHCUELQL-UHFFFAOYSA-N
Catalogue number
GC19902
Brand
GLPBIO
Computed properties PubChem CID 51116434 · XLogP 2.6 · TPSA 85.3 Ų · H-bond donors 2
XLogP
2.6
TPSA
85.3 Ų
H-bond donors
2
H-bond acceptors
4
Rotatable bonds
7
Heavy atoms
27

SMILES CCOC(=O)C1=CC=C(C=C1)NC(=O)NCC2=CC=C(C=C2)N3C=CC=N3

Computed descriptors from PubChem (CID 51116434), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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