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Chemical structure of TMB 8 (hydrochloride)

GC19438

TMB 8 (hydrochloride)

Also known as diethyl-[8-(3,4,5-trimethoxybenzoyl)oxyoctyl]azanium chloride

TMB 8 is a non-competitive antagonist of nicotinic acetylcholine receptors (nAChRs) with IC50 values of 390 and 350 nM, respectively, for human muscle-type and α3β4 subunit-containing ganglionic nAChRs expressed in TE671/RD or SH-SY5Y cells

ChemicalCAS53464-72-5MW432FormulaC22H37NO5 • HCl
CAS number
53464-72-5
Molecular weight
432
Formula
C22H37NO5 • HCl
Solubility
Chloroform： Slightly Soluble,Methanol： Slightly Soluble,Water： Slightly Soluble
InChIKey
KFJZVXKPPQIYCG-UHFFFAOYSA-N
Catalogue number
GC19438
Brand
GLPBIO
Computed properties PubChem CID 150613 · TPSA 58.4 Ų · H-bond donors 1 · H-bond acceptors 6
TPSA
58.4 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
16
Heavy atoms
29

SMILES CC[NH+](CC)CCCCCCCCOC(=O)C1=CC(=C(C(=C1)OC)OC)OC.[Cl-]

Computed descriptors from PubChem (CID 150613), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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