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Chemical structure of WNK463

GC19383

WNK463

Also known as N-tert-butyl-3-[1-[5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]-2-pyridinyl]piperidin-4-yl]imidazole-4-carboxamide

WNK463 inhibits the pan-With-No-Lysine (K) (WNK) kinase, demonstrating IC50 values of 5 nM, 1 nM, 6 nM, and 9 nM for WNK1, WNK2, WNK3, and WNK4, respectively

ChemicalCAS2012607-27-9MW463.46FormulaC21H24F3N7O2
CAS number
2012607-27-9
Molecular weight
463.46
Formula
C21H24F3N7O2
Solubility
DMSO ： ≥ 30 mg/mL (64·73 mM)
InChIKey
HWSHOMMVLGBIDN-UHFFFAOYSA-N
Catalogue number
GC19383
Brand
GLPBIO
Computed properties PubChem CID 121487936 · XLogP 2.6 · TPSA 102 Ų · H-bond donors 1
XLogP
2.6
TPSA
102 Ų
H-bond donors
1
H-bond acceptors
10
Rotatable bonds
5
Heavy atoms
33

SMILES CC(C)(C)NC(=O)C1=CN=CN1C2CCN(CC2)C3=NC=C(C=C3)C4=NN=C(O4)C(F)(F)F

Computed descriptors from PubChem (CID 121487936), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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