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Chemical structure of VH-298

GC19375

VH-298

Also known as (2S,4R)-1-[(2S)-2-[(1-cyanocyclopropanecarbonyl)amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

VH-298 is a highly potent inhibitor of the VHL:HIF-α interaction with a Kd value of 80 to 90 nM, used in PROTAC technology

ChemicalCAS2097381-85-4MW523.65FormulaC27H33N5O4S
CAS number
2097381-85-4
Molecular weight
523.65
Formula
C27H33N5O4S
Solubility
DMSO ： ≥ 83·3 mg/mL (159·08 mM)
InChIKey
NDVQUNZCNAMROD-RZUBCFFCSA-N
Catalogue number
GC19375
Brand
GLPBIO
Computed properties PubChem CID 122199236 · XLogP 2.5 · TPSA 164 Ų · H-bond donors 3
XLogP
2.5
TPSA
164 Ų
H-bond donors
3
H-bond acceptors
7
Rotatable bonds
8
Heavy atoms
37

SMILES CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)C4(CC4)C#N)O

Computed descriptors from PubChem (CID 122199236), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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