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Chemical structure of Repotrectinib

GC19362

Repotrectinib

Also known as (3R,11S)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentazatetracyclo[13.5.2.04,9.018,22]docosa-1(21),4(9),5,7,15(22),16,19-heptaen-14-one

TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 5·3 nM, 1·01 nM, 1·26 nM and 1·08 nM for SRC, WT ALK, ALK G1202R and ALK L1196M, respectively

ChemicalCAS1802220-02-5MW355.37FormulaC18H18FN5O2
CAS number
1802220-02-5
Molecular weight
355.37
Formula
C18H18FN5O2
Solubility
DMSO ： ≥ 83·3 mg/mL (234·40 mM)
InChIKey
FIKPXCOQUIZNHB-WDEREUQCSA-N
Catalogue number
GC19362
Brand
GLPBIO
Computed properties PubChem CID 135565923 · XLogP 2.1 · TPSA 80.6 Ų · H-bond donors 2
XLogP
2.1
TPSA
80.6 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
0
Heavy atoms
26

SMILES C[C@H]1CNC(=O)C2=C3N=C(C=CN3N=C2)N[C@@H](C4=C(O1)C=CC(=C4)F)C

Computed descriptors from PubChem (CID 135565923), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.