Loading...
Chemical structure of Tenapanor

GC19352

Tenapanor

Also known as 1-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-3-[4-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylcarbamoylamino]butyl]urea

Tenapanor is an inhibitor of the Na+/H+ exchanger NHE3 with IC50 values of 5 and 10 nM against human and Rat NHE3, respectively

ChemicalCAS1234423-95-0MW1145.05FormulaC50H66Cl4N8O10S2
CAS number
1234423-95-0
Molecular weight
1145.05
Formula
C50H66Cl4N8O10S2
Solubility
DMSO ： 50 mg/mL (43·67 mM);Water ： ＜ 0·1 mg/mL (insoluble)
InChIKey
DNHPDWGIXIMXSA-CXNSMIOJSA-N
Catalogue number
GC19352
Brand
GLPBIO
Computed properties PubChem CID 71587953 · XLogP 5.1 · TPSA 235 Ų · H-bond donors 6
XLogP
5.1
TPSA
235 Ų
H-bond donors
6
H-bond acceptors
14
Rotatable bonds
29
Heavy atoms
74

SMILES CN1C[C@H](C2=C(C1)C(=CC(=C2)Cl)Cl)C3=CC(=CC=C3)S(=O)(=O)NCCOCCOCCNC(=O)NCCCCNC(=O)NCCOCCOCCNS(=O)(=O)C4=CC=CC(=C4)[C@@H]5CN(CC6=C5C=C(C=C6Cl)Cl)C

Computed descriptors from PubChem (CID 71587953), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.