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Chemical structure of Senexin B

GC19326

Senexin B

Also known as 4-[2-[6-(4-methylpiperazine-1-carbonyl)naphthalen-2-yl]ethylamino]quinazoline-6-carbonitrile

Senexin B is a potent, highly water-soluble and bioavailable CDK8/19 inhibitor, with Kds of 140 nM for CDK8 and 80 nM for CDK19

ChemicalCAS1449228-40-3MW450.53FormulaC27H26N6O
CAS number
1449228-40-3
Molecular weight
450.53
Formula
C27H26N6O
Solubility
DMSO ： 6 mg/mL (13·32 mM)
InChIKey
VNADJTWHOAMTLY-UHFFFAOYSA-N
Catalogue number
GC19326
Brand
GLPBIO
Computed properties PubChem CID 71661259 · XLogP 4.1 · TPSA 85.2 Ų · H-bond donors 1
XLogP
4.1
TPSA
85.2 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
5
Heavy atoms
34

SMILES CN1CCN(CC1)C(=O)C2=CC3=C(C=C2)C=C(C=C3)CCNC4=NC=NC5=C4C=C(C=C5)C#N

Computed descriptors from PubChem (CID 71661259), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.